Selective drug delivery to bone using acidic oligopeptides

Targeted drug delivery to bone: pharmacokinetic and pharmacological properties of acidic oligopeptide-tagged drugs.

Site-specific drug delivery to bone is considered to be achievable by utilizing acidic amino acid homopeptides. We found that fluorescence-labeled acidic amino acid (L-Asp or L-Glu) homopeptides containing six or more residues bound strongly to hydroxyapatite, which is a major component of bone, and were selectively delivered to and retained in bone after systemic administration. We explored th...

Experimental Studies of Model Drug Delivery Using Superpulse CO2 Laser

Tadalafil Transdermal Drug Delivery Using Microemulsion Formulation in Laboratory Model

Background and purpose: Tadalafil has gained wide clinical acceptance in treatment of erectile dysfunction due to its long treatment window and lower potential for visual impairment. Transdermal drug delivery prevents systemic elimination, drug-drug and food-drug interactions, and reduces side effects by reducing the dose of the drug. The aim of this study was to evaluate the effect of microemu...

DRUG DELIVERY TO THE POSTERIOR EYE USING ETCHED MICRONEEDLES DRUG DELIVERY TO THE POSTERIOR EYE USING ETCHED MICRONEEDLES By

Niosomes from Preparation to Application in Drug Delivery

Introduction: In recent years, the treatment strategy for infectious and autoimmune diseases has significantly changed. Up to now, cancer treatment has been conducted on the basis of clinical and pathological methods. The most common cancer treatments is limited to chemotherapy, radiation therapy and surgery. However, cancer treatment is still not optimal. Common challenges for treatment of cer...